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T*
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T*
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[(ai)-4.9(d)-448.4(k)1.7(i)-4.9(t)-449.2(for)-449.2(t)-4.3(he)-449(systems)-449.2(m)9.3(e)-9.4(d)1.6(icine)-449(r).8(esearchers)-449.2(f)-4.9(a)1.4(ci)-4.9(ng)]TJ
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[(an)-345.3(unfamil)-5.1(i)-.3(ar)-341.2(t)-4.9(e).5(rm.)-342.3(T)-3.3(he)-4.7(y)-340.3(w)-2.3(ill)-341.4(h)-3.5(ere)-346.1(g)1.1(et)-341.1(a)-345.8()1.7(r)-4.9(s).2(t)-341.1(u)1(nde)-4.7(r).2(-)]TJ
T*
.0092 Tc
[(st)-4.4(anding)-350.2(of)-351.6(it;)-352.2(a)1.3(nd,)-352.2(m)-1.3(ore)-350.8(i)-5(m)9.2(p)-9(or)-4.4(tantly,)-347(e)-4.2(xamples)-351(and)]TJ
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[(references)-304.1(for)-304.1(d)1.9(igging)-298(into)-302.6(the)-303.8(t)1.2(opic.)]TJ
.9984 -1.1795 TD
0 Tc
[(Science,)-304.7(in)-306.1(general,)-304(and)-302.3(medicine,)-305.5(in)-300.9(particular,)-304.1(can)]TJ
-.9984 -1.1847 TD
[(benet)-361.7(from)-360.9(approaches)-363(that)-362.8(are)-366(different)-359.9(from)-366.1(what)]TJ
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[(was)-203.3(done)-200.9(earlier,)-203.1(as)-202.6(these)-200.7(can)-199.3(have)-201.4(multiplicative)-201.7(effects)]TJ
0 -1.1847 TD
[(on)-350.6(kn)21.2(ow)18.2(l)12(e)12.5(dg)15.8(e)-360(a)12.8(nd)-351.3(un)21.2(de)15.2(r)12.2(s)0(t)19.3(a)12.8(nd)16(i)11.7(n)0(g)-351.2(i)11.7(n)-364.3(g)13.1(en)20.6(er)19.5(al)19.7(;)-361.4(t)12.3(hi)20.2(s)-365.4(m)15.3(ay)]TJ
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[(l)12(e)0(a)20.1(d)-292.2(to)-284.4(ne)20.6(w)-290.4(i)0(n)19.8(s)0(i)18.7(g)0(h)21.6(t)0(s)-280.7(a)0(n)15.8(d)-292.2(i)11.7(d)0(e)20.3(a)0(s)-280.2(f)0(o)20.2(r)-293(ne)20.6(w)-295.6(h)13.7(yp)21(ot)20.8(he)15.8(s)12.2(e)12.5(s,)-287.1(a)12.8(n)0(d)]TJ
0 -1.1847 TD
[(ev)20.4(en)20.7(tu)20.2(al)19.7(ly)-487(t)12.3(o)-493.2(br)20.8(ea)20.1(kt)20.2(hr)15.6(o)13.7(u)0(g)21(h)0(s)-486.2(u)0(n)21.2(a)0(t)19.9(t)0(a)19.9(i)0(n)19.8(a)0(b)21.3(l)0(e)-487.6(v)13.1(ia)-487.7(t)12.3(h)0(e)-486(o)0(l)20.6(d)]TJ
0 -1.1795 TD
[(an)21(d)-271.5(t)0(e)19.6(s)0(t)19.3(e)0(d)-264.2(w)14.8(ay)20.7(s)-272.3(o)0(f)-264.3(t)12.3(hi)20.2(nk)21.2(i)11.7(n)0(g)-263.3(a)0(n)21(d)-271.5(ac)20.1(ti)18.8(ng)21.3(.)-273.5(I)12.3(n)-271.2(t)0(u)20.2(r)0(n)20.4(,)-273.4(t)12.3(h)0(i)20.2(s)-272.3(re)19.5(-)]TJ
T*
[(qu)21.2(ir)18.7(es)-285.7(c)12.5(r)0(o)20.8(s)0(s)19.3(i)0(n)19.8(g)-297.3(d)13(i)0(s)18.7(c)12.5(ip)19.5(li)18.5(ne)-284.6(bo)22.3(un)21.2(da)15.5(r)12.2(i)11.7(es)-285.7(an)21(d)-297.4(p)13(ro)20.8(vi)19.6(de)20.3(s)-298.2(n)13.3(ew)]TJ
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[(an)21(gl)20(es)-394.3(to)-398.2(o)13.7(l)0(d)-394(i)0(n)19.8(f)0(o)20.2(r)0(m)17.2(a)12.8(ti)18.8(on)21.9(.)-408(W)11(e)-406.5(e)12.5(xp)20.6(ec)19.8(t)-406.7(t)0(h)20.8(i)0(s)-395.1(g)0(l)20(o)0(s)20.8(s)0(a)19.8(r)0(y)-393.7(t)0(o)]TJ
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/Cs8 cs 1 scn
[(Concepts)-301.7(from)-299.4(Systems)-297(Medicine,)-305.2(Modeling,)]TJ
0 -1.2411 TD
[(and)-298.4(Data)-304.4(Science)]TJ
/F9 1 Tf
10.959 0 0 10.959 62.022 105.1086 Tm
0 0 0 rg
[(All)-318.4(terms)-318.3(are)-319.4(included)-317.9(here)-321.6(in)-316.4(alphabetical)-318.9(order,)-318.4(and)]TJ
0 -1.1847 TD
[(they)-320.9(are)-319.4(further)-321.1(listed)-319.4(in)-321.6(Table)-317.9(1.)-322.1(Table)-317.9(2)-322.8(also)-316.5(reports)]TJ
22.9068 55.2753 TD
[(a)-323.5(list)-313.9(of)-321.2(the)-318.5(acronyms)-319(that)-316.2(appear)-316.8(in)-321.6(the)-318.5(text,)-316.7(and)-323(the)]TJ
0 -1.1847 TD
[(corresponding)-614.6(meaning.)-610.8(Finally,)-609.7(underlined)-613.1(words,)]TJ
0 -1.1795 TD
[(for)-490.1(example,)-482.6(agent-based)-485.1(modeling)-485(\(ABM\),)-484.7(refer)-487.3(to)]TJ
0 -1.1847 TD
[(terms)-302.7(that)-295.5(are)-303.9(dened)-299.6(here.)]TJ
/F5 1 Tf
10.4607 0 0 10.4607 313.0582 633.0896 Tm
/Cs8 cs 1 scn
[(Agent-based)-300.9(modeling)]TJ
/F9 1 Tf
10.959 0 0 10.959 313.0582 620.1636 Tm
0 0 0 rg
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[(ABM)-711.1(\(also)-713.4(known)-713(as)-709.7(Individual-based)-716.5(modeling,)]TJ
T*
0 Tc
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-.0001 Tc
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0 -1.1847 TD
0 Tc
[(pecially)-397(suited)-396(for)-391.8(studying)-394.8(complex)-394.5(systems,)-390.5(that)-393.8(is,)]TJ
0 -1.1795 TD
[(systems)-267.1(composed)-261.3(of)-264.3(a)-266.6(large)-263.3(number)-266.5(of)-264.3(heterogeneous)]TJ
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[(interacting)-317.5(entities,)-314.6(with)-309.6(each)-315.8(having)-310.3(many)-312.7(degrees)-315.5(of)]TJ
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[(freedom.)-342.9(A)-342.5(very)-342.2(open)-340.6(denition)-345.2(of)-336.8(this)-343.3(mathematical)]TJ
T*
[(discrete)-346(modeling)-340.2(paradigm)-340.9(is)-343.4(to)-341.3(represent)-342.5(a)-339(physical)]TJ
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[(or)-491.4(biological)-488.7(system)-486.2(on)-490.3(the)-484(basis)-490.9(of)-486.8(entities)-491.3(\(called)]TJ
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[(agents\))-408.5(with)-402.8(dened)-408.2(properties)-407.5(and)-405.7(behavioral)-404.6(rules,)]TJ
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0 -1.1795 TD
[(the)-328.8(real)-328.1(phenomena)-324.7(and)-323(to)-325.8(perform)-328.4(what-if)-324.4(analysis.)]TJ
8.2191 0 0 7.3052 548.2203 482.5699 Tm
(6)Tj
10.959 0 0 10.959 313.0582 464.7117 Tm
[(Agents)-211.8(have,)-211(thus,)-211.9(to)-211.9(be)-206.6(understood)-212.4(as)-212.9(autonomou)7.1(s)-215.4(en-)]TJ
T*
[(tities,)-361.2(each)-357.2(one)-358.8(with)-361.4(an)-356.7(internal)-360.2(state)-356.9(representing)-361.3(its)]TJ
0 -1.1847 TD
[(knowledge)-295.8(about)-291.4(the)-297.8(environment,)-290.5(and)-297.1(rules)-295(\(or)-293.2(algo-)]TJ
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[(rithms\))-309(to)-310.2(interact)-309.1(with)-309.6(other)-308.1(agents.)-311(This)-310.6(broad)-307(de-)]TJ
T*
[(nition)-451.6(can)-447.7(then)-450(encompass)-446.3(from)-448.9(simple)-450.9(particles)-447.5(to)]TJ
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[(autonomous)-301.4(software)-306.5(with)-299.3(learning)-307.7(capabilities.)-300.4(To)-303.5(il-)]TJ
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(7,8)Tj
10.959 0 0 10.959 363.6282 374.0597 Tm
[(robotic)-236.1(agents)-244.5(to)-237.8(explore)-242.4(inhospitable)-240.5(envi-)]TJ
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(ronments,)Tj
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(9)Tj
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[(reaction)-406(simulation.)]TJ
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(1012)Tj
10.959 0 0 10.959 426.2172 348.1511 Tm
[(Roughly)-398.9(speaking,)-404.5(an)-403.2(entity)]TJ
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[(attribute:)-403.8(An)-401.6(agent)-406.7(must)-402.4(be)-398(identiable.)-403.3(In)-403.8(addition,)]TJ
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[(agents)-234.2(can)-230.4(be)-232.4(identied)-227.7(on)-231.6(the)-230.5(basis)-232.2(of)-228.1(four)-233.9(basic)-232(prop-)]TJ
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[(erties:)-417.3(autonomy,)-414.5(that)-414.5(is,)-415.1(the)-416.8(behavior)-408.8(of)-419.5(each)-414.1(agent)]TJ
T*
[(is)-384.8(not)-379.7(guided)-384.1(by)-381.9(rules)-382.9(dened)-382.4(at)-378.4(a)-380.4(higher)-383.6(tier;)-380(social)]TJ
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[(ability,)-331(that)-326.6(is,)-332.3(their)-325.6(capacity)-328.7(of)-331.6(interacting)-327.9(with)-330.3(other)]TJ
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[(agents;)-657.6(reactivity,)-656.3(in)-657.8(that)-652.5(they)-652(react)-656.8(to)-656.8(perceived)]TJ
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[(changes)-375.5(in)-373.3(the)-370.2(environment;)-373.3(and)-374.7(pro-activeness,)-371(that)]TJ
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[(also)-378.6(conceptually)-374.9(important)-374.8(to)-372.3(dene)-379.9(what)-375.8(the)-375.4(agent)]TJ
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[(embedded)-225.5(in)-218.1(the)-220.2(behavioral)-223.6(rules)-217.4(or)-222.4(be)-222.1(explicitly)-217.8(repre-)]TJ
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[(sented)-488(as)-482(a)-483.8(different)-484.1()47.3(modeled)-486.6(object)46.4()-480.4(with)-485.5(a)-483.8(well-)]TJ
T*
[(dened)-310(set)-309.6(of)-305.7(characteristics)-310.6(that)-305.9(inuence)-306.2(the)-308.1(agents)]TJ
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(behavior.)Tj
1.0036 -1.1795 TD
[(An)-339.5(ABM)-343.7(simulation)-337.5(may)-341.6(start)-341.7(from)-340.3(simple)-342.3(agents,)]TJ
-1.0036 -1.1847 TD
[(locally)-698.1(interacting)-695.2(with)-697.6(simple)-699.2(rules)-693.3(of)-698.9(behavior,)]TJ
0 -1.1795 TD
[(responding)-373.7(to)-367.1(perceived)-368.1(environmental)-369.9(cues)-368.8(and)-369.5(try-)]TJ
0 -1.1847 TD
[(ing)-468.9(to)-460.3(achieve)-464.8(a)-463.1(local)-464.6(goal.)-465(However,)-464.1(the)-463.3(simplicity)]TJ
0 -1.1795 TD
[(of)-279.9(the)-271.9(composing)-274.6(elements)-275(does)-274.5(not)-276.2(derive)-271.6(in)-280.2(the)-271.9(sim-)]TJ
0 -1.1847 TD
[(plicity)-622.4(of)-621.3(the)-618.5(overall)-615.2(dynamics.)-619.6(From)-623.4(this)-617.5(simple)]TJ
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[(suggestio)-13.4(n)-301.6(coming)-301.1(from)-305.5(reade)-10.9(rs.)]TJ
7.9702 0 0 7.9702 62.022 755.2061 Tm
(Zanin,)Tj
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[(et)-300.9(al.;)-297.1(Network)-296.2(and)-299.8(Systems)-294.3(Medicine)]TJ
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[(http://onl)9.4(ine.liebertpu)9.7(b.com/doi/1)9.2(0.1089/nsm.20)9.5(20.0003)]TJ
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