Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/12143
Title: Granulomatosis with polyangitis (Wegener’s) and central nervous system involvement: Case report
Authors: Tomic Lucic, Aleksandra
Veselinovic, Mirjana
Pantovic, Suzana
Petrovic, Dejan
Živanović, Sandra
Milovanovic, Jasmina
Journal: Srpski Arhiv za Celokupno Lekarstvo
Issue Date: 1-Jan-2015
Abstract: Introduction Granulomatosis with polyangitis (Wegener’s) is an antineutrophil cytoplasmic antibody (PR3-ANCA)-associated vasculitis, which commonly involves the upper and lower respiratory tracts and kidneys. Central nervous system involvement is reported in less than 11%, and rarely present at onset. Case Outline We report the case of a 41-year-old male patient with a high disease activity, large organ involvement, as well as central nervous system manifestations presented at onset. Treatment with intravenous pulse methylprednisolone, followed by the pulsed doses of cyclophosphamide was induced. After 6 months of cyclophosphamide pulse therapy a remission was achieved. Next, azathioprine was used for maintenance during the next 18 months. There were no disease flares during 24-month follow-up. Conclusion Granulomatosis with polyangitis (Wegener’s) with large organ involvement, affecting the central nervous system structures require a rapid diagnosis and intensive medication treatment in order to prevent or reduce irreversible damage. Our experience confirms the findings reported in the literature that the severe forms of the disease are associated with increased probability of achieving remission, which reflects increased responsiveness of such patients to immunosuppressant therapy.
URI: https://scidar.kg.ac.rs/handle/123456789/12143
Type: article
DOI: 10.2298/SARH1502083T
ISSN: 03708179
SCOPUS: 84924365852
Appears in Collections:Faculty of Hotel Management and Tourism, Vrnjačka Banja
Faculty of Medical Sciences, Kragujevac

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