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Title: Mesenchymal stem cell-derived exosomes as new remedy for the treatment of neurocognitive disorders
Authors: Harrell C.
Volarevic, Ana
Djonov, Valentin
Volarevic, Vladislav
Journal: International Journal of Molecular Sciences
Issue Date: 1-Feb-2021
Abstract: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. Mesenchymal stem cell (MSC)-derived exosomes (MSC-Exo) are nano-sized extracellular vesicles enriched with MSC-sourced neuroprotective and immunomodulatory microRNAs, neural growth factors, and anti-inflammatory cytokines, which attenuate neuro-inflammation, promote neo-vascularization, induce neurogenesis, and reduce apoptotic loss of neural cells. Accordingly, a large number of experimental studies demonstrated MSC-Exo-dependent improvement of cognitive impairment in experimental animals. In this review article, we summarized current knowledge about molecular and cellular mechanisms that were responsible for MSC-Exo-based restoration of cognitive function, emphasizing therapeutic potential of MSC-Exos in the treatment of neurocognitive disorders.
Type: Review
DOI: 10.3390/ijms22031433
ISSN: 16616596
SCOPUS: 85100109395
Appears in Collections:Faculty of Medical Sciences, Kragujevac
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