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|Title:||Mesenchymal stem cell-derived exosomes as new remedy for the treatment of neurocognitive disorders|
|Journal:||International Journal of Molecular Sciences|
|Abstract:||© 2021 by the authors. Licensee MDPI, Basel, Switzerland. Mesenchymal stem cell (MSC)-derived exosomes (MSC-Exo) are nano-sized extracellular vesicles enriched with MSC-sourced neuroprotective and immunomodulatory microRNAs, neural growth factors, and anti-inflammatory cytokines, which attenuate neuro-inflammation, promote neo-vascularization, induce neurogenesis, and reduce apoptotic loss of neural cells. Accordingly, a large number of experimental studies demonstrated MSC-Exo-dependent improvement of cognitive impairment in experimental animals. In this review article, we summarized current knowledge about molecular and cellular mechanisms that were responsible for MSC-Exo-based restoration of cognitive function, emphasizing therapeutic potential of MSC-Exos in the treatment of neurocognitive disorders.|
|Appears in Collections:||Faculty of Medical Sciences, Kragujevac|
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