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Назив: Psoriasis between Autoimmunity and Oxidative Stress: Changes Induced by Different Therapeutic Approaches
Аутори: Medovic M.
Jakovljevic, Vladimir
Zivkovic, Vladimir
Jeremic, Nevena
Jeremic, Jovana
Bolevich, Sergey
Ravic Nikolic, Ana
Milicic, Vesna
Srejovic, Ivan
Датум издавања: 2022
Сажетак: Psoriasis is defined as chronic, immune-mediated disease. Regardless of the development of new therapeutic approaches, the precise etiology of psoriasis remains unknown and speculative. The aim of this review was to systematize the results of previous research on the role of oxidative stress and aberrant immune response in the pathogenesis of psoriasis, as well as the impact of certain therapeutic modalities on the oxidative status in patients with psoriasis. Complex immune pathways of both the innate and adaptive immune systems appear to be major pathomechanisms in the development of psoriasis. Oxidative stress represents another important contributor to the pathophysiology of disease, and the redox imbalance in psoriasis has been reported in skin cells and, systemically, in plasma and blood cells, and more recently, also in saliva. Current immune model of psoriasis begins with activation of immune system in susceptible person by some environmental factor and loss of immune tolerance to psoriasis autoantigens. Increased production of IL-17 appears to be the most prominent role in psoriasis pathogenesis, while IL-23 is recognized as master regulator in psoriasis having a specific role in cross bridging the production of IL-17 by innate and acquired immunity. Other proinflammatory cytokines, including IFN-γ, TNF-α, IL-1β, IL-6, IL-22, IL-26, IL-29, or IL-36, have also been reported to play important roles in the development of psoriasis. Oxidative stress can promote inflammation through several signaling pathways. The most noticeable and most powerful antioxidative effects exert various biologics compared to more convenient therapeutic modalities, such as methotrexate or phototherapy. The complex interaction of redox, immune, and inflammatory signaling pathways should be focused on further researches tackling the pathophysiology of psoriasis, while antioxidative supplementation could be the solution in some refractory cases of the disease.
URI: https://scidar.kg.ac.rs/handle/123456789/15976
Тип: review
DOI: 10.1155/2022/2249834
ISSN: 1942-0900
SCOPUS: 2-s2.0-85126901754
Налази се у колекцијама:Faculty of Medical Sciences, Kragujevac

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