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Назив: Synthesis and DNA binding properties of some new tryptamine Schiff’s bases
Аутори: Marjanović, Jovana S
Radisavljević, Snežana
Divac, Vera
Kostic, Marina
Датум издавања: 2023
Сажетак: The synthesis of Schiff’s bases by reaction of tryptamine and seven different aldehydes has been performed in absolute ethanol. The required Schiff bases were obtained in good yields. Schiff bases are known as compounds with a wide range of biological activities, such as antifungal, antibacterial, anti-malarial, antiproliferative, anti-inflammatory and antipyretic [1]. In this study, we presented the synthesis and DNA binding properties of seven novel tryptamine-derived Schiff bases. UV-Vis spectroscopic method was used for the determination of the binding mode between exanimated substances and DNA. In order to obtain the binding strength of compounds to DNA molecules we’ve calculated intrinsic binding constants Kb (M−1) for tested compounds from the Wolfe–Shimmer equation [2]. All synthesized compounds showed high values for Kb (104 M−1) which indicates the strong binding of examined compounds to DNA.
URI: https://scidar.kg.ac.rs/handle/123456789/19410
Тип: conferenceObject
Налази се у колекцијама:Institute for Information Technologies, Kragujevac

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