Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/9077
Title: Cannabis as a possible treatment for spasticity in multiple sclerosis
Authors: Vesić, Katarina
Dejanovic S.
Borovcanin, Milica
Samardzic J.
Toncev, Gordana
Journal: Serbian Journal of Experimental and Clinical Research
Issue Date: 1-Mar-2016
Abstract: © 2016, University of Kragujevac, Faculty of Science. All Rights Reserved. The therapeutic potential of cannabis has been known for centuries. Cannabinoids express their effects throughtwotypes of receptors, cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2). Present studies indicate that cannabis-based drugs can make a positive impact in the treatment of different diseases. For many years, multiple sclerosis patients have self-medicated with illegal street cannabis to alleviate spasticity, a common and debilitating symptom that impairs quality of life. Nabiximols is the cannabis-based medicine approved in many countries as an add-on therapy for symptom improvement in patients with spasticity who have not responded adequately to other medications. Adverse events such as dizziness, diarrhoea, fatigue, nausea, headache and somnolence occur quite frequently with nabiximols, but they are generally of mild-to-moderate intensity and their incidence can be markedly reduced by gradual uptitration. The prerequisite for the therapeutic use of cannabis in Serbia arerequires legal clarifi cation for the use of the drug in a clinical environment.
URI: https://scidar.kg.ac.rs/handle/123456789/9077
Type: review
DOI: 10.1515/SJECR-2015-0047
ISSN: 18208665
SCOPUS: 84961574721
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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