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Title: Multiscale modeling of circular and elliptical particles in laminar shear flow
Authors: Filipovic, Nenad
Isailovic, Velibor
Djukic, Tijana
Ferrari M.
Kojić M.
Journal: IEEE Transactions on Biomedical Engineering
Issue Date: 1-Jan-2012
Abstract: Drug delivery systems for cancer prevention and pain management have been improved related to classical cancer chemotherapy. Nanotechnology with nanoparticles offers new ways in transport of drug molecules and contrast agents by the blood flow through the circulatory system. In this study, we use multiscale mesoscopic bridging procedure of the finite elements (FE) coupled with dissipative particle dynamics (DPD) and lattice Boltzmann (LB) method to model the motion of circular and elliptical particles in a 2-D laminar flow. Four examples are considered: 1) one sedimenting cylinder in a channel, 2) two sedimenting cylinders in a channel, 3) motion of four elliptical particles in a linear shear flow, and 4) motion of circular and elliptical particle in the arterial bifurcation geometry. A good agreement with solution from the literature available was found. These results show that the multiscale approach with coupled FE and DPD/LB methods can effectively be applied to model motion of micro/nanoparticles for a drug delivery system. © 2011 IEEE.
Type: Article
DOI: 10.1109/TBME.2011.2166264
ISSN: 00189294
SCOPUS: 84555202612
Appears in Collections:Faculty of Engineering, Kragujevac
Institute for Information Technologies, Kragujevac
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