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https://scidar.kg.ac.rs/handle/123456789/10879
Назив: | Deletion of Galectin-3 attenuates acute pancreatitis in mice by affecting activation of innate inflammatory cells |
Аутори: | Stojanovic B. Jovanovic I. Stojanovic B. Stojanovic, Mirjana Gajovic N. Radosavljevic, Gordana Pantic, Jelena Arsenijevic, Nebojsa Lukic, Miodrag |
Датум издавања: | 2019 |
Сажетак: | © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Acute pancreatitis is characterized by autodigestion of pancreatic cells followed by acute inflammation leading to pathology and death. In experimental acute pancreatitis, pancreatic acinar cells and infiltrating macrophages express Galectin-3 but its role in pathology of this disease is unknown. Therefore, we studied its role using Galectin-3 deficient mice. Deletion of Galectin-3 prolonged the survival of mice, led to attenuation of histopathology, and decreased infiltration of mononuclear cells and neutrophils that express TLR-4, in particular, pro-inflammatory N1 neutrophils. Galectin-3 and TLR-4 are also colocalized on infiltrating cells. Lack of Galectin-3 reduced expression of pro-inflammatory TNF-α and IL-1β in F4/80+CD11c- and CD11c+F4/80− cells. Thus, deletion of Galectin-3 ameliorates acute pancreatitis by attenuating early influx of neutrophils and inflammatory mononuclear cells of innate immunity. These findings provide the basis to consider Galectin-3 as a therapeutic target in acute pancreatitis. |
URI: | https://scidar.kg.ac.rs/handle/123456789/10879 |
Тип: | article |
DOI: | 10.1002/eji.201847890 |
ISSN: | 0014-2980 |
SCOPUS: | 2-s2.0-85063726865 |
Налази се у колекцијама: | Faculty of Medical Sciences, Kragujevac |
Датотеке у овој ставци:
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10.1002-eji.201847890.pdf | 1.05 MB | Adobe PDF | Погледајте |
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