Молимо вас користите овај идентификатор за цитирање или овај линк до ове ставке: https://scidar.kg.ac.rs/handle/123456789/10879
Назив: Deletion of Galectin-3 attenuates acute pancreatitis in mice by affecting activation of innate inflammatory cells
Аутори: Stojanovic B.
Jovanovic I.
Stojanovic B.
Stojanovic, Mirjana
Gajovic N.
Radosavljevic, Gordana
Pantic, Jelena
Arsenijevic, Nebojsa
Lukic, Miodrag
Датум издавања: 2019
Сажетак: © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Acute pancreatitis is characterized by autodigestion of pancreatic cells followed by acute inflammation leading to pathology and death. In experimental acute pancreatitis, pancreatic acinar cells and infiltrating macrophages express Galectin-3 but its role in pathology of this disease is unknown. Therefore, we studied its role using Galectin-3 deficient mice. Deletion of Galectin-3 prolonged the survival of mice, led to attenuation of histopathology, and decreased infiltration of mononuclear cells and neutrophils that express TLR-4, in particular, pro-inflammatory N1 neutrophils. Galectin-3 and TLR-4 are also colocalized on infiltrating cells. Lack of Galectin-3 reduced expression of pro-inflammatory TNF-α and IL-1β in F4/80+CD11c- and CD11c+F4/80− cells. Thus, deletion of Galectin-3 ameliorates acute pancreatitis by attenuating early influx of neutrophils and inflammatory mononuclear cells of innate immunity. These findings provide the basis to consider Galectin-3 as a therapeutic target in acute pancreatitis.
URI: https://scidar.kg.ac.rs/handle/123456789/10879
Тип: article
DOI: 10.1002/eji.201847890
ISSN: 0014-2980
SCOPUS: 2-s2.0-85063726865
Налази се у колекцијама:Faculty of Medical Sciences, Kragujevac

Број прегледа

489

Број преузимања

29

Датотеке у овој ставци:
Датотека Опис ВеличинаФормат 
10.1002-eji.201847890.pdf1.05 MBAdobe PDFСличица
Погледајте


Ова ставка је заштићена лиценцом Креативне заједнице Creative Commons