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https://scidar.kg.ac.rs/handle/123456789/11095
Назив: | Synthesis, characterization and anticancer activity of novel ferrocene containing quinolinones: 1-Allyl-2-ferrocenyl-2,3-dihydroquinolin-4(1H)-ones and 1-allyl-2-ferrocenylquinolin-4(1H)-ones |
Аутори: | Pejović, Anka ![]() ![]() Drabowicz, Jozef ![]() Cieślak M. Kazmierczak-Barańska J. Krolewska-Golinska K. |
Датум издавања: | 2018 |
Сажетак: | © 2018 Elsevier B.V. A two new series of ferrocene containing quinolinones – 1-allyl-2-ferrocenyl-2,3-dihydroquinolin-4(1H)-ones and 1-allyl-2-ferrocenylquinolin-4(1H)-ones – were prepared and characterized by standard spectroscopic techniques and cyclic voltammetry. The in vitro antitumor activity of all synthesized compounds was investigated against Human Cervix Carcinoma (HeLa), Chronic Myelogenous Leukemia (K562) and normal endothelial (HUVEC) cell lines using the MTT method. Quinolone derivative 5c exhibited the highest cytotoxic activity in the cell growth inhibition of HeLa cell line while 5f was the most toxic against K562 cells. |
URI: | https://scidar.kg.ac.rs/handle/123456789/11095 |
Тип: | article |
DOI: | 10.1016/j.jorganchem.2018.08.004 |
ISSN: | 0022-328X |
SCOPUS: | 2-s2.0-85051679959 |
Налази се у колекцијама: | Faculty of Science, Kragujevac |
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