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https://scidar.kg.ac.rs/handle/123456789/11125
Назив: | In vitro study of iron coordination properties, anti-inflammatory potential, and cytotoxic effects of N-salicylidene and N-vanillidene anil Schiff bases |
Аутори: | Petrović, Zorica Đorović Jovanović, Jelena Simijonović, Dušica Trifunović, Srećko Petrović, Vladimir |
Датум издавања: | 2018 |
Сажетак: | © 2018, Institute of Chemistry, Slovak Academy of Sciences. N-Salicylidene and N-vanillidene anil Schiff bases SB-1–5 were evaluated for their iron-coordinating properties. For this purpose, reactions with Fe(III) chloride were performed. The obtained results showed that salicylaldehyde bases SB-1 and SB-2 are the best coordinating ligands among the investigated SBs. The corresponding complexes are obtained in good yield and investigated using UV–Vis spectrophotometry and IR spectroscopy. The inhibitory potential of SB-1–5 against iron-containing enzyme lipoxygenase (LOX) was also tested. Salicylidene bases exerted better activity then vanilliden. The cytotoxic in vitro activities against human breast carcinoma MDA-MB-231 and human colon carcinoma HCT-116 cell lines were determined. Based on these results, SB-1 and SB-2 can be considered as interesting compounds for further in vivo investigations. |
URI: | https://scidar.kg.ac.rs/handle/123456789/11125 |
Тип: | article |
DOI: | 10.1007/s11696-018-0419-5 |
ISSN: | 0366-6352 |
SCOPUS: | 2-s2.0-85050726703 |
Налази се у колекцијама: | Faculty of Science, Kragujevac Institute for Information Technologies, Kragujevac |
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In vitro study of iron coordination properties, anti-inflammatory potential, and cytotoxic effects of N-salicylidene and N-vanillidene anil Schiff bases.pdf Ограничен приступ | 1.2 MB | Adobe PDF | Погледајте |
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