Part XXIII. Synthesis and characterization of platinum(IV) complexes with O,O′-dialkyl esters of (S,S)-ethylenediamine-N,N′-di-2-(3-methyl)butanoic acid and bromido ligands. Antimicrobial, antibiofilm and antioxidant screening

Abstract

© 2015 Published by Elsevier B.V. Four new platinum(IV) complexes C1-C4 of general formula [PtBr4(R2-S,S-eddv)], (R = ethyl, propyl, butyl and pentyl; S,S-eddv = (S,S) - ethylenediamine-N,N′-di-2-(3-methyl)butanoate) have been synthesized and characterized by microanalysis, infrared, 1H and 13C NMR spectroscopy. In vitro antimicrobial activity for these and [PtBr4(R2-S,S-eddp)] complexes (S,S-eddp = (S,S)-ethylenediamine-N,N′-di-2-propanoate) has been investigated. The antibacterial activity was tested against 16 strains of bacteria determining the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) using microdilution method. In general, platinum(IV) complexes manifested moderate activity against the Gram positive bacteria and low activity against the Gram negative bacteria. The complexes showed weak antioxidative properties tested by two methods (DPPH and reducing power assay).