An overview of pharmacological and non-pharmacological treatment as a useful tool for the protection from cardiotoxicity of antineoplastic drugs

Abstract

© 2020, University of Kragujevac, Faculty of Science. All rights reserved. Unfortunately, in patients with cancer disease, clinical application of antineoplastic drug results in severe side effects of cardiotoxicity. We aim to review the research focused on elimination or reduction of antineoplastic drug-induced cardiotoxicity without affecting its anticancer efficacy by different agens. This study is based on pertinent papers that were re-trieved by a selective search using relevant keywords in PubMed and ScienceDirect. Based on mentioned purpose, various strategies were investigated and proposed, and thou-sands of compounds were screened. The literature mainly focusing on drugs, natural products and herb extracts with therapeutic efficacies as well as non-pharmacological treatment against differently induced cardiotoxicity during treatment in patients with cancers. Larger future studies are necessary to reach a point of secure cytostatic therapy, improved patient survival and qu-ality of life. Until that moment, baseline and serial cardiac evaluation is recommended to facilitate early identification and treatment of cardiotoxicity.