КOMPLEKSI ZLATA KAO POTENCIJALNI SUPLEMENTI SA ANTIKANCEROGENIM I ANTIVIRUSNIM DELOVANJEM

Abstract

The pharmacologic properties of gold compounds have been known since the end of the 19th century. They have been used for different studies, even though they are usually used for the treatment of arthritis. In the last decade, gold complexes have received increased attention due to the variety of their applications. Primary, they have been investigated as potential anticancer and chemotherapeutic agents. It is well known that gold(III) complexes are very similar to platinum(II) compounds, so they could exhibit prospective anticancer, cytotoxic and antitumor properties. In this paper, were investigated the interactions of the gold(III) complexes, [Au(DPP)Cl2]+ and [Au(DMP)Cl3] where DPP=4,7-diphenyl-1,10-phenanthroline and DMP=2,9-dimethyl-1,10-phenanthroline) with SARS-CoV2 protease. The obtained results indicate that the square-planar [Au(DPP)Cl2]+ complex shows good inhibitory activity, compared to FDA approved drugs, cinanserin and chloroquine.