Молимо вас користите овај идентификатор за цитирање или овај линк до ове ставке: https://scidar.kg.ac.rs/handle/123456789/14022
Назив: Novel and emerging therapeutics for genetic epilepsies
Аутори: Pejcic, Ana
Jankovic, Slobodan
Đešević M.
Gojak R.
Lukic, Snezana
Marković N.
Milosavljević, Miloš
Датум издавања: 2021
Сажетак: Introduction: Disease-specific treatments are available only for a minority of patients with genetic epilepsies, while the rest are treated with anticonvulsants, which are ineffective in almost one-third of patients. Areas covered: Recently approved and the most effective emerging therapeutics under development for the treatment of genetic epilepsies are overviewed after systematic search and analysis of relevant literature. Expert opinion: New and emerging drugs for genetic epilepsies exploit one of the two approaches: inhibiting hyperactive brain foci through blocking excitatory or augmenting inhibitory neurotransmission, or correcting the underlying genetic defect. The first is limited by insufficient selectivity of available compounds, and the second by imperfection of currently used vectors of genetic material, unselective and transient transgene expression. Besides, the treatment may come too late, after structural abnormalities and epilepsy deterioration takes place. However, with recent improvements, we can expect to see soon gradual decline in the number of patients with therapy-resistant genetic epilepsies.
URI: https://scidar.kg.ac.rs/handle/123456789/14022
Тип: article
DOI: 10.1080/14737175.2021.1992275
ISSN: 1473-7175
SCOPUS: 2-s2.0-85118121820
Налази се у колекцијама:Faculty of Medical Sciences, Kragujevac

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