Ferrocene-containing tetrahydropyrimidin-2(1H)-ones: Antioxidant and antimicrobial activity

Abstract

A small library of ferrocenes that contain six-membered cyclic ureas ring were smoothly synthesized, in moderate to good yields. The purity of >95% and structural characterization for obtained compounds have been established by standard spectroscopic methods, as well as elemental analysis. The electrochemical properties of the prepared compounds have been provided using cyclic voltammetry. Seventeen ferrocene-containing tetrahydropyrimidin-2(1H)-ones were screened for in vitro antioxidant, antibacterial, and antifungal activity. The antioxidant activity of synthesized compounds was determined using two methods: ABTS radical cation and DPPH radical scavenging activities. The antimicrobial potential was evaluated in vitro employing three bacterial strains and three fungal strains. The synthesized compounds showed significantly lower antimicrobial activity compared with commercial antimicrobial compounds, while some of the synthesized ferrocenyl derivatives possess strong ABTS·+ scavenging activity.