Investigating the potential inhibitory effect of the megaphone (molecule) on nasopharyngeal cancer growth factor receptors

Abstract

Nasopharyngeal cancer (NPC) is a type of cancer that originates in the nasopharynx, which is the upper part of the throat behind the nasal cavity. Like other cancers, the growth and progression of nasopharyngeal cancer are influenced by various proteins involved in cell signaling, growth regulation, and tumor development such as Epidermal Growth Factor Receptor (EGFR), Vascular Endothelial Growth Factor (VEGF), Fibroblast growth factor receptor (FGFR) and Cyclin D1 (CD1). Megaphone ((1′R,5′R,7R,8S)-7-Hydroxy-3,4,5,5′-methoxy-5′,6′-dihydro-2′H-8,1′-neolign-8′-en-2′-one, MG) is the main component of the alcohol extract of the ground root of Aniba megaphylla, which in vitro inhibits the growth of cells derived from human nasopharyngeal carcinoma. Due to the lack of literature data, the main goal of this study was to examine the first step of the mechanisms of anti-carcinogenic activity by examining the inhibitory potential of MG against the above-mentioned cancer cell growth factor receptors.