FOTELP-VOX-OA: Enhancing radiotherapy planning precision with particle transport simulations and Optimization Algorithms

Abstract

Accurate tumor targeting with minimal exposure to healthy tissue remains a significant challenge in radiotherapy. Modern techniques like Intensity-Modulated Radiation Therapy and stereotactic radiotherapy increasingly rely on detailed simulations and planning to achieve maximum treatment efficiency. Particle transport simulations play a crucial role in accurately modeling interactions between radiation and biological structures, providing a foundation for advancements in treatment planning. Building on this, FOTELP-VOX-OA is introduced as a novel framework designed to determine the optimal external-beam radiotherapy treatment plan. The primary aim of this study is to integrate the existing FOTELP-VOX framework with various Optimization Algorithms, focusing on estimating the parameters of interest that lead to the optimal radiation dose. While the framework itself is not pathology-specific, ocular melanoma is chosen as a test case due to its requirement for exceptionally precise dose delivery, given the small tumor volume and proximity of critical ocular structures.