Synthesis, characterization, and antifungal activities of novel ferrocenyl pyrazolines containing sulfonamide moiety

Abstract

A series of novel ferrocenyl pyrazolines containing sulfonamide moiety was prepared in a two-step reaction. All new derivatives were characterized by NMR spectroscopy and physical data. The antifungal potential of the synthesized ferrocenyl pyrazolines was evaluated on different fungal species, with several compounds exhibiting moderate antifungal effects. Notably, compounds exhibited MIC values in the range of 0.5–2 mg/mL against Penicillium canescens and Candida albicans, indicating selective antifungal activity and potential for further development as antifungal agents.