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https://scidar.kg.ac.rs/handle/123456789/9036
Title: | Regulatory role of peritoneal B cells in EAE |
Authors: | Stojanovic B. Milovanovic, Jelena Arsenijevic A. Milovanovic, Marija Lukic, Miodrag |
Issue Date: | 2016 |
Abstract: | © 2016, University of Kragujevac, Faculty of Science, All rights reserved. B cells play a dual role in the pathogenesis of autoimmune diseases. In experimental autoimmune encephalomyelitis (EAE), an experimental model for multiple sclerosis, B cells contribute to disease progression, while their regulatory role predominates in the initial phases of disease development. Several studies have identified different subsets of regulatory B cells, mostly in the spleen, which are all sources of IL-10. However, peritoneal regulatory B cells are also important producers of IL-10, can migrate towards inflammatory stimuli, and could have an immunoregulatory function. As we have observed expansion of regulatory B cells in the peritoneum of resistant mice after EAE induction, herein we discuss the regulatory roles of B cells in EAE pathogenesis and the possible role of peritoneal regulatory B cells in resistance to EAE induction. |
URI: | https://scidar.kg.ac.rs/handle/123456789/9036 |
Type: | review |
DOI: | 10.1515/SJECR-2015-0048 |
ISSN: | 1820-8665 |
SCOPUS: | 2-s2.0-84971009727 |
Appears in Collections: | Faculty of Medical Sciences, Kragujevac |
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10.1515-SJECR-2015-0048.pdf | 264.07 kB | Adobe PDF | View/Open |
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