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Title: Regulatory role of peritoneal B cells in EAE
Authors: Stojanovic B.
Milovanovic, Jelena
Arsenijevic A.
Milovanovic, Marija
Lukic, Miodrag
Issue Date: 2016
Abstract: © 2016, University of Kragujevac, Faculty of Science, All rights reserved. B cells play a dual role in the pathogenesis of autoimmune diseases. In experimental autoimmune encephalomyelitis (EAE), an experimental model for multiple sclerosis, B cells contribute to disease progression, while their regulatory role predominates in the initial phases of disease development. Several studies have identified different subsets of regulatory B cells, mostly in the spleen, which are all sources of IL-10. However, peritoneal regulatory B cells are also important producers of IL-10, can migrate towards inflammatory stimuli, and could have an immunoregulatory function. As we have observed expansion of regulatory B cells in the peritoneum of resistant mice after EAE induction, herein we discuss the regulatory roles of B cells in EAE pathogenesis and the possible role of peritoneal regulatory B cells in resistance to EAE induction.
Type: review
DOI: 10.1515/SJECR-2015-0048
ISSN: 1820-8665
SCOPUS: 2-s2.0-84971009727
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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