SCIDAR - A Digital Archive of the University of Kragujevac

Isorhamnetin Modulates Drug-Resistance-Related Biomarkers in Colon Cancer Cells

The development of resistance to standard cytostatics, such as 5-fluorouracil (5-FU), significantly limits the efficacy of colon cancer therapy, prompting the search for novel anticancer agents, particularly among natural compounds. This study evaluated the anticancer effects of isorhamnetin, a plant-derived flavonol, and its ability to modulate the expression of drug-resistance-related biomarkers in SW-480 and HT-29 colon cancer cells, with a focus on ATP-binding cassette (ABC) transporters....

Integrated automatic configuration system for modular strongroom: Development, integration and implementation

The paper presents the Integrated Automatic Configuration System (IAKS) for modular strongroom (MSR). IAKS encompasses the processes of generating possible product variants, choosing the optimal configuration (variant) of the product, and detailed CAD design of the product and technological process. The system is composed of nine interconnected modules that facilitate the automation of various design phases. The modules for conceptual configuration, optimization, and CAD configuration, which ...

SUCCESS OF AI MATH SOLVER TOOL IN SOLVING NON-STANDARD MATHEMATICS COMPETITION PROBLEMS

Artificial intelligence is increasingly transforming how students learn, including their approach to mathematics and problem-solving, by offering additional support and assistance—a trend that continues to attract research interest. One line of research focuses on helping students prepare for math competitions by solving more complex mathematical problems. In addition to regular national math competitions, which allow students to progress to international mathematical Olympiads, there are als...

Карактеристичне врсте репера кривих у геометрији простора Минковског

U ovoj doktorskoj disertaciji definisani su i istraženi karakteristični re- peri duž krivih u prostorima Minkovskog. Uveden je Bišopov reper (reper sa svojstvom minimalne rotacije) pseudo nul krive i parcijalno nul krive u prostor- vremenu Minkovskog E41 . Izvedene su jednačine Bišopovog repera i dobijena je od- govarajuća relacija između Freneovog i Bišopovog repera. Pomoću geometrijske algebre prostor-vremena, određeni su Darbuovi bivektori Freneovog i Bišopovog repera pseudo nul kri...

Развој композита на бази биомасе за унапређење термичких и звучних својстава грађевинских објеката

У дисертацији су приказани резултати сопственог експерименталног истраживања три врсте биокомпозита који су засновани на млевеном окласку кукуруза, пиљевини и гранулама експандираног полистирена као агрегата док се као везиво користи мешавина креча и гипса. На предметним мешавинама испитани су одређени параметри као што су порозност, упијање воде, чврстоће при притиску и савијању, отпор протока ваздуха, коефицијент топлотне проводљивости, специфични топлотни капацитет и фактор отпора д...

PROBLEM OPROŠTAJA U ROMANU „ČITAČ“ BERNHARDA ŠLINKA: IZMEĐU ŽRTVE I ZLOČINCA

The paper primarily dealt with the topic of forgiveness in Bernhard Schlink’s novel The Reader. Forgiveness has been discussed from the perspectives of the victims and the perpetrators. A multidisciplinary approach has been applied in the research, namely the moral philosophy has been applied to a particular literary work. The theoretical framework consisted of the following works: Forgiveness and Christian Ethics by Anthony Bash, On Cosmopolitanism and forgiveness by Jacques Derrida, Forgive...

JEZIČKI TRANSFER U PISANOJ PRODUKCIJI NA ITALIJANSKOM KAO DRUGOM STRANOM JEZIKU

La ricerca si concentra sull’analisi del trasferimento linguistico nella produzione scritta degli studenti che apprendono l’italiano come seconda lingua straniera e la cui prima lingua straniera è il francese o lo spagnolo. Gli aspetti chiave della ricerca riguardano gli errori fatti nelle produzioni scritte, ovvero i trasferimenti linguistici, che possono essere positivi, facilitando l’apprendimento grazie alle somiglianze tra le lingue, o negativi, causando errori a causa delle differenze l...

SEMANTIČKA ADAPTACIJA GERMANIZAMA ZABELEŽENIH U INTERNET SERVISU „VUKAJLIJA“

Using contrastive analysis, the paper compares the original meaning of Germanisms with their meaning in Serbian as the recipient language. The Germanisms were analysed from the point of view of the synchronic linguistic approach. Based on semantic criteria, the corpus was extracted from the Vukajlija Internet service, originally designed as a slang dictionary. The goal of the paper was to analyse the meaning of loanwords originating from the German language and their meaning in Serbian, as th...

(NE)DOVOLjNOST KOMPARATIVNOG I POZITIVNOG STEPENA U SRPSKOM I ENGLESKOM JEZIKU

Contemporary literature often classifies categorically diverse lexemes into adverbial intensifiers. The paper presents the results of independent corpus analyses of two languages. The largest available electronic corpora are used here: Corpus of Contemporary American English (COCA) and Korpus savremenog srpskog jezika 2013 (KSSJ). A semasiological approach is used to identify adverbs signifying (in)sufficiency of the degree expressed by comparatives and positives. The contrastive analyses exp...