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https://scidar.kg.ac.rs/handle/123456789/9088
Назив: | Synthesis of Angularly Fused (Homo)triquinane-Type Hydantoins as Precursors of Bicyclic Prolines |
Аутори: | Šmit, Biljana Rodic, Marko Pavlovic, Radoslav |
Датум издавања: | 2016 |
Сажетак: | © Georg Thieme Verlag Stuttgart · New York-Synthesis 2016. An efficient strategy for a four-step synthesis of angularly fused tricyclic hydantoins as suitable precursors of cis-fused bicyclic α-amino acids is developed by combining a highly diastereoselective Bucherer-Bergs reaction of 2-alkenylcycloalkanones and a regiospecific selenium-induced closure of pyrrolidine ring. This methodology was applied in a five-step synthesis of bicycloproline derivatives in high overall yield. The method could be used for the multigram preparation of free conformationally constrained bicyclic α-amino acids with two points of diversity (size of cycloalkyl ring and substituent at the pyrrolidine ring). |
URI: | https://scidar.kg.ac.rs/handle/123456789/9088 |
Тип: | article |
DOI: | 10.1055/s-0035-1561285 |
ISSN: | 0039-7881 |
SCOPUS: | 2-s2.0-84955188563 |
Налази се у колекцијама: | Institute for Information Technologies, Kragujevac |
Датотеке у овој ставци:
Датотека | Опис | Величина | Формат | |
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10.1055-s-0035-1561285.pdf | 3.97 MB | Adobe PDF | Погледајте |
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