Cytotoxicity of platinum(iv) and palladium(ii) complexes with meso-1,2-diphenyl-ethylenediamine-N,N'-DI-3-propanoic acid. crystal structure of [pd(1,2-dpheddp)] complex

Abstract

The syntheses of tetradentate ligand, meso-1,2-diphenyl-ethylenediamine-N,N'-di-3-propanoic acid (H2-1,2-dpheddp) and corresponding platinum(IV) and palladium(II) complexes are reported here. The spectroscopically predicted structure of the obtained palladium(II) complex was confirmed by X-ray analysis. Singe crystals suitable for X-ray measurements were obtained by slow crystallization from a DMSO-water mixture. Cytotoxic effects of platinum(IV), palladium(II) complexes and cisplatin on the 4T1 and B16F1 cell lines were determined using the MTT colorimetric technique. The complexes showed a dose dependence on cytotoxic effect toward both cell lines. Both complexes were less active than cis-platin, the exception was concentrations above 62.5 μM of platinum(IV) complex in the B16F1 cell line.