Молимо вас користите овај идентификатор за цитирање или овај линк до ове ставке: https://scidar.kg.ac.rs/handle/123456789/9163
Назив: Relationship between the bioavailability and molecular properties of angiotensin II receptor antagonists
Аутори: Trbojevic J.
Odovic J.
Trbojevic-Stanković J.
Nešić D.
Jelic, Ratomir
Датум издавања: 2016
Сажетак: In the present study, we investigated the relationships between several molecular properties and bioavailability data for seven of the most commonly prescribed angiotensin II receptor antagonists (also known as angiotensin II receptor blockers (ARBs) or sartans), candesartan, eprosartan, irbesartan, losartan, olmesartan, telmisartan and valsartan. The molecular descriptors of ARBs are:, aqueous solubility (logS values), polar surface area (PSA), molecular weight (Mw), volume value (Vol), lipophilicity (logP values) and the acidity descriptor (pKa1). The respective descriptors were calculated using four different software packages. The relevant bioavailability data were obtained from literature. Among calculated molecular descriptors, simple linear regression analysis showed the best correlation between bioavailability data and the lipophilicity descriptor, logP (R2=0.568). Multiple linear regression established good correlations between bioavailability and the lipophilicity descriptor, logP, using the molecular weight, Mw, or the acidity descriptor, pKa1, as an additional, independent variable (with R2=0.661 and 0.682, respectively). Finally, excluding candesartan from the calculations resulted in a very good correlation (R2=0.852) between the remaining ARB bioavailability and molecular descriptors MlogP and Mw as independent variables, determined by multiple linear regression.
URI: https://scidar.kg.ac.rs/handle/123456789/9163
Тип: article
DOI: 10.2298/ABS150915015T
ISSN: 0354-4664
SCOPUS: 2-s2.0-84970974472
Налази се у колекцијама:Faculty of Medical Sciences, Kragujevac

Број прегледа

168

Број преузимања

19

Датотеке у овој ставци:
Датотека Опис ВеличинаФормат 
10.2298-ABS150915015T.pdf1.07 MBAdobe PDFСличица
Погледајте


Ова ставка је заштићена лиценцом Креативне заједнице Creative Commons