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Назив: Galectin-3 in obesity and type 2 diabetes
Аутори: Pejnović, Nada
Датум издавања: 2015
Сажетак: © 2015, University of Kragujevac, Faculty of Science. All rights reserved. Galectin-3 is an important regulator of inflammation and acts as a receptor for advanced-glycation (AGE) and lipoxidation end-products (ALE). Evidence indicates a significant upregulation in circulating levels and visceral adipose tissue production of Galectin-3 in obesity and type 2 diabetes. Recent studies demonstrate development of obesity and dysregulation of glucose metabolism in Galectin-3 “knockout” (KO) mice, which also develop accelerated and more severe pathology in models of atherosclerosis and metabolically-induced kidney damage. Thus, evidence that Galectin-3 is an important player in metabolic disease is accumulating. This review discusses current evidence on the connection between Galectin-3 and metabolic disease, focusing on mechanisms by which this galectin modulates adiposity, glucose metabolism and obesity-associated inflammatory responses.
URI: https://scidar.kg.ac.rs/handle/123456789/9199
Тип: article
DOI: 10.1515/SJECR-2015-0057
ISSN: 1820-8665
SCOPUS: 2-s2.0-84950244419
Налази се у колекцијама:Faculty of Medical Sciences, Kragujevac

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