Thyroid function in haemodialysis patients

Abstract

© Serbian Medical Society 2015. All rights reserved. Objective. The aim of this study was to evaluate thyroid function in patients on regular hemodialysis and the impact of hemodialysis parameters on thyroid function. Methods. This clinical study was performed including 50 patients selected from the total number of patients on regular hemodialysis at the Centre for Nephrology and Dialysis Centre in Clinical Centre during 2014. All patients were clinically and laboratory tested (standard laboratory analyses, hormonal parameters of thyroid function TSH, fT3 and fT4 and parameters of quality of hemodialysis - URRUrea Reduction Ratio and single-pool index Kt/V). The results were analyzed by using appropriate statistics. Results. In the study patients, the mean levels of hormone fT3 levels were below the reference value, while the middle level of hormones TSH and fT4 levels were within normal values. Decreased function of the thyroid gland was registered in 8% of patients. Non-thyroidal illness was registered in 52% of patients. In the patients participating in the study, the effects on thyroid function were influenced by the following factors: Kt/V as a parameter of hemodialysis adequacy, PTH concentrations <150 and > 1000 pg/ml, calcium concentrations <2.24 and > 2:54 mmol/ml. Conclusion. End stage renal failure and hemodialysis affect thyroid function in several ways. Decreased function of the thyroid gland appeared in 8% of the patients. Euthyroid sick syndrome was registered in 52% of patients.