Stereospecific ligands and their complexes. Part XV. Synthesis, characterization and cytotoxicity of novel platinum(IV) complexes with some esters of ethylenediamine-N, N' N′ -di-S, S-(2,2′ -dibenzyl)acetic acid. Crystal structure of O, O′ -dipropyl-ethylenediamine -N, N′ -di-S, S-(2,2′ -dibenzyl)acetate dihydrochloride

Abstract

The synthesis of ethylenediamine-N,N′'-di-S,S-(2,2′'-dibenzyl) acetic acid (H2-S,S-eddba) and its ethyl-, propyl-, butyl- esters (R2-S,S-eddba) are reported here. The esters were used for synthesis of the corresponding platinum(IV) complexes, [PtCl4(R 2-S,S-eddba)]. The compounds were characterized by elemental analysis, infrared, 1H and 13C NMR spectroscopy. The structure of propyl ester of H2-S,S-eddba was confirmed by single-crystal X-ray analysis. All [PtCl4(R2-S,S-eddba)] complexes displayed significantly higher in vitro cytotoxicity in comparison to cisplatin. © 2013 Published by Elsevier B.V.