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Title: Stereospecific ligands and their complexes. Part XV. Synthesis, characterization and cytotoxicity of novel platinum(IV) complexes with some esters of ethylenediamine-N, N' N′ -di-S, S-(2,2′ -dibenzyl)acetic acid. Crystal structure of O, O′ -dipropyl-ethylenediamine -N, N′ -di-S, S-(2,2′ -dibenzyl)acetate dihydrochloride
Authors: Dimitrijević D.
Glocrossed D Signović V.
Radic G.
García-Granda, Santiago
Menéndez-Taboada L.
Milovanovic, Marija
Volarevic, Vladislav
Arsenijevic, Nebojsa
Bogdanovic, Goran A.
Trifunović, Srećko
Issue Date: 2013
Abstract: The synthesis of ethylenediamine-N,N′'-di-S,S-(2,2′'-dibenzyl) acetic acid (H2-S,S-eddba) and its ethyl-, propyl-, butyl- esters (R2-S,S-eddba) are reported here. The esters were used for synthesis of the corresponding platinum(IV) complexes, [PtCl4(R 2-S,S-eddba)]. The compounds were characterized by elemental analysis, infrared, 1H and 13C NMR spectroscopy. The structure of propyl ester of H2-S,S-eddba was confirmed by single-crystal X-ray analysis. All [PtCl4(R2-S,S-eddba)] complexes displayed significantly higher in vitro cytotoxicity in comparison to cisplatin. © 2013 Published by Elsevier B.V.
Type: article
DOI: 10.1016/j.ica.2013.03.039
ISSN: 0020-1693
SCOPUS: 2-s2.0-84877087811
Appears in Collections:Faculty of Medical Sciences, Kragujevac
Faculty of Science, Kragujevac

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