Synthesis of new Pt(II) complex bearing organoselenium ligands and evaluation of cytotoxic activity of some structurally related Pd(II) complexes

Abstract

© 2020, Macedonian Journal of Chemistry and Chemical Engineering. Herein we report the synthesis of a new trans-bis(2-phenylselenylmethyl)oxolane)dichloroplati-num(II) complex (Pt1). This newly synthesized complex, together with two structurally related trans-Pd(II) complexes, (trans-bis(2-(phenylselenylmethyl)oxolane) dichloropalladium(II) (Pd1) and trans-bis(2-(phenylselenylmethyl)oxane)dichloropalladium(II) (Pd2), were screened for cytotoxic activity through in vitro studies on the HCT-116 colorectal carcinoma cell line and MRC-5 healthy lung pleura cell line. The activity of the complexes was assessed by comparing it to cisplatin. The cells' viability and proliferation were determined using an MTT (Microculture Tetrazolium Test) assay.