Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/10675
Title: Synthesis of new Pt(II) complex bearing organoselenium ligands and evaluation of cytotoxic activity of some structurally related Pd(II) complexes
Authors: Radenković N.
Kostic, Marina
Đorđević, Nevena
Dolicanin Z.
V. Soldatovic, Tanja
Živanović, Marko
Divac, Vera
Journal: Macedonian Journal of Chemistry and Chemical Engineering
Issue Date: 1-Jan-2020
Abstract: © 2020, Macedonian Journal of Chemistry and Chemical Engineering. Herein we report the synthesis of a new trans-bis(2-phenylselenylmethyl)oxolane)dichloroplati-num(II) complex (Pt1). This newly synthesized complex, together with two structurally related trans-Pd(II) complexes, (trans-bis(2-(phenylselenylmethyl)oxolane) dichloropalladium(II) (Pd1) and trans-bis(2-(phenylselenylmethyl)oxane)dichloropalladium(II) (Pd2), were screened for cytotoxic activity through in vitro studies on the HCT-116 colorectal carcinoma cell line and MRC-5 healthy lung pleura cell line. The activity of the complexes was assessed by comparing it to cisplatin. The cells' viability and proliferation were determined using an MTT (Microculture Tetrazolium Test) assay.
URI: https://scidar.kg.ac.rs/handle/123456789/10675
Type: article
DOI: 10.20450/mjcce.2020.1905
ISSN: 18575552
SCOPUS: 85086509019
Appears in Collections:Faculty of Science, Kragujevac
Institute for Information Technologies, Kragujevac

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