Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/11460
Title: Cytotoxic and Antimicrobial Activity of Dehydrozingerone based Cyclopropyl Derivatives
Authors: Burmudz̃ija A.
Muškinja, Jovana
Kosanic, Marijana
Ranković B.
Novakovic, Sladjana B.
Dordević Z.
Stanojkovic, Tatjana
Baskić D.
Ratković, Zoran
Issue Date: 2017
Abstract: © 2017 Wiley-VHCA AG, Zurich, Switzerland A small series of 1-acetyl-2-(4-alkoxy-3-methoxyphenyl)cyclopropanes was prepared, starting from dehydrozingerone (4-(4-hydroxy-3-methoxyphenyl)-3-buten-2-one) and its O-alkyl derivatives. Their microbiological activities toward some strains of bacteria and fungi were tested, as well as their in vitro cytotoxic activity against some cancer cell lines (HeLa, LS174 and A549). All synthesized compounds showed significant antimicrobial activity and expressed cytotoxic activity against tested carcinoma cell lines, but they showed no significant influence on normal cell line (MRC5). Butyl derivative is the most active on HeLa cells (IC50 = 8.63 μm), while benzyl one is active against LS174 and A549 cell lines (IC50 = 10.17 and 12.15 μm, respectively).
URI: https://scidar.kg.ac.rs/handle/123456789/11460
Type: article
DOI: 10.1002/cbdv.201700077
ISSN: 1612-1872
SCOPUS: 2-s2.0-85021654218
Appears in Collections:Faculty of Science, Kragujevac
Institute for Information Technologies, Kragujevac

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