Please use this identifier to cite or link to this item:
|Title:||Cytotoxic and Antimicrobial Activity of Dehydrozingerone based Cyclopropyl Derivatives|
Novakovic, Sladjana B.
|Journal:||Chemistry and Biodiversity|
|Abstract:||© 2017 Wiley-VHCA AG, Zurich, Switzerland A small series of 1-acetyl-2-(4-alkoxy-3-methoxyphenyl)cyclopropanes was prepared, starting from dehydrozingerone (4-(4-hydroxy-3-methoxyphenyl)-3-buten-2-one) and its O-alkyl derivatives. Their microbiological activities toward some strains of bacteria and fungi were tested, as well as their in vitro cytotoxic activity against some cancer cell lines (HeLa, LS174 and A549). All synthesized compounds showed significant antimicrobial activity and expressed cytotoxic activity against tested carcinoma cell lines, but they showed no significant influence on normal cell line (MRC5). Butyl derivative is the most active on HeLa cells (IC50 = 8.63 μm), while benzyl one is active against LS174 and A549 cell lines (IC50 = 10.17 and 12.15 μm, respectively).|
|Appears in Collections:||Faculty of Science, Kragujevac|
Institute for Information Technologies, Kragujevac
|[ Google Scholar ]|
Files in This Item:
|29.86 kB||Adobe PDF|
Items in SCIDAR are protected by copyright, with all rights reserved, unless otherwise indicated.