Part XVI - Stereospecific ligands and their complexes: Synthesis, characterization and In Vitro antiproliferative activity of new platinum(iv) complexes with some O,O'-dialkyl esters of (S,S)-ethylenediamine-N,N'-di-2-propanoic acid against breast cancer (MDA-MB-231) and colon cancer (HCT-116 and SW-480) cell lines

Abstract

Synthesis of four new platinum(IV) complexes (C1-C4) with bidentate N,N'-ligand precursors, O,O'-dialkyl esters (L1-L4) (alkyl = ethyl, propyl, butyl and pentyl) of (S,S)-ethylenediamine-N,N'-di-2-propanoic acid, H2-S,S-eddp were reported. The platinum(IV) complexes were characterized by elemental analysis and their structures determined on the basis of infra-red, 1H and 13C NMR spectroscopy. Cyto-toxicity against human breast carcinoma MDA-MB-231, human colon carcinoma HCT-116 and SW-480 tumour cell lines was determined using the MTT assay, which indicated the larger the size of the complex or ligand, the greater the cytotoxicity.