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Title: Part XVI - Stereospecific ligands and their complexes: Synthesis, characterization and In Vitro antiproliferative activity of new platinum(iv) complexes with some O,O'-dialkyl esters of (S,S)-ethylenediamine-N,N'-di-2-propanoic acid against breast cancer (MDA-MB-231) and colon cancer (HCT-116 and SW-480) cell lines
Authors: Jevtić, Verica
Radic G.
Šeklić, Dragana
Živanović, Marko
Marković, Snežana
Trifunović, Srećko
Issue Date: 2014
Abstract: Synthesis of four new platinum(IV) complexes (C1-C4) with bidentate N,N'-ligand precursors, O,O'-dialkyl esters (L1-L4) (alkyl = ethyl, propyl, butyl and pentyl) of (S,S)-ethylenediamine-N,N'-di-2-propanoic acid, H2-S,S-eddp were reported. The platinum(IV) complexes were characterized by elemental analysis and their structures determined on the basis of infra-red, 1H and 13C NMR spectroscopy. Cyto-toxicity against human breast carcinoma MDA-MB-231, human colon carcinoma HCT-116 and SW-480 tumour cell lines was determined using the MTT assay, which indicated the larger the size of the complex or ligand, the greater the cytotoxicity.
Type: article
DOI: 10.20450/mjcce.2014.148
ISSN: 1857-5552
SCOPUS: 2-s2.0-84902596792
Appears in Collections:Faculty of Science, Kragujevac
Institute for Information Technologies, Kragujevac

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