Green one-pot synthesis of pyrido-dipyrimidine DNA-base hybrids in water

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Назив:	Green one-pot synthesis of pyrido-dipyrimidine DNA-base hybrids in water
Аутори:	Milović E. Janković, Nenad Vranes, Milan Stefanovic D. Petronijević, Jelena Joksimović N. Muškinja, Jovana Ratković, Zoran
Датум издавања:	2021
Сажетак:	© 2020, Springer Nature Switzerland AG. Reactions in water as a safe and cheap solvent is a major goal of green chemistry. Actual synthesis of pyrido-dipyrimidine scaffold, named DNA-base hybrids, involves catalysis in hazardous solvents. Here we synthesised pyrido-dipyrimidines by one-pot heterocyclization of thiobarbituric acid, vanillic aldehydes and amines in water. Enamine and vanillidene are key intermediates of the Biginelli-like reaction mechanism. Our synthetic method displays several benefits such as the use of a green medium and various substrates, and yields up to 99%.
URI:	https://scidar.kg.ac.rs/handle/123456789/12578
Тип:	article
DOI:	10.1007/s10311-020-01076-9
ISSN:	1610-3653
SCOPUS:	2-s2.0-85089546020
Налази се у колекцијама:	Faculty of Science, Kragujevac Institute for Information Technologies, Kragujevac