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Title: Green one-pot synthesis of pyrido-dipyrimidine DNA-base hybrids in water
Authors: Milović E.
Janković, Nenad
Vranes, Milan
Stefanovic D.
Petronijević, Jelena
Joksimović N.
Muškinja, Jovana
Ratković, Zoran
Journal: Environmental Chemistry Letters
Issue Date: 1-Feb-2021
Abstract: © 2020, Springer Nature Switzerland AG. Reactions in water as a safe and cheap solvent is a major goal of green chemistry. Actual synthesis of pyrido-dipyrimidine scaffold, named DNA-base hybrids, involves catalysis in hazardous solvents. Here we synthesised pyrido-dipyrimidines by one-pot heterocyclization of thiobarbituric acid, vanillic aldehydes and amines in water. Enamine and vanillidene are key intermediates of the Biginelli-like reaction mechanism. Our synthetic method displays several benefits such as the use of a green medium and various substrates, and yields up to 99%.
Type: Article
DOI: 10.1007/s10311-020-01076-9
ISSN: 16103653
SCOPUS: 85089546020
Appears in Collections:Faculty of Science, Kragujevac
Institute for Information Technologies, Kragujevac
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