IN VIVO PROTEKTIVNI EFEKAT EKSTRAKATA BILJKE Lysimachia vulgaris NA DNK OŠTEĆENJA INDUKOVANA ETIL METANSULFONATOM 2022ЗБОРНИК БИОДИВЕРЗИТЕТ

Abstract

The in vivo genotoxic activity of the aerial part and root methanol extracts of Lysimachia vulgaris L. and ability to protect DNA from ethyl methanesulfonate- induced DNA damage was studied using comet assays in Drosophila melanogaster. Results revealed no significant differences in mean genetic damage index between exposure groups (20, 40, 80 mg mL-1 of Drosophila food) and negative control, indicating a non-genotoxic effect. Combined treatment of extracts and ethyl methanesulfonate showed a significant reduction in DNA damage with a percentage of reduction above 80. These findings suggest that the methanolic extract of L. vulgaris could be used as a natural agent in the prevention of diseases associated with DNA damage.