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https://scidar.kg.ac.rs/handle/123456789/9475| Title: | Inhibitory effect of cisplatin and [Pt(dach)Cl2] on the activity of phospholipase A2 |
| Authors: | Nesic, Maja  Kamčeva T. Bugarčić, Živadin Petkovic, Marijana |
| Issue Date: | 2013 |
| Abstract: | This work has been focused on testing the influence of two selected Pt(II) complexes cisplatin, Pt(NH3)2Cl2, and [Pt(dach)Cl2] on the activity of porcine pancreatic phospholipase A2 (PLA2). It has been assumed that this enzyme plays a role in carcinogenesis and that it could be a target in the tumour therapy. The results of this study show that both Pt(II) complexes inhibit the activity of the enzyme, though they bind to it in a different manner. While cisplatin interacts with the enzyme in an acompetitive manner, the stable interaction of [Pt(dach)Cl2] with PLA2 could not be detected under our experimental conditions. © 2013 Informa UK, Ltd. |
| URI: | https://scidar.kg.ac.rs/handle/123456789/9475 |
| Type: | article |
| DOI: | 10.3109/14756366.2012.666539 |
| ISSN: | 1475-6366 |
| SCOPUS: | 2-s2.0-84880057888 |
| Appears in Collections: | Faculty of Science, Kragujevac |
 | Page views(s)513 | Downloads(s)27 |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 10.3109-14756366.2012.666539.pdf | 973.11 kB | Adobe PDF |  View/Open |
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