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Title: Inhibitory effect of cisplatin and [Pt(dach)Cl2] on the activity of phospholipase A2
Authors: Nesic, Maja
Kamčeva T.
Bugarčić, Živadin
Petkovic, Marijana
Issue Date: 2013
Abstract: This work has been focused on testing the influence of two selected Pt(II) complexes cisplatin, Pt(NH3)2Cl2, and [Pt(dach)Cl2] on the activity of porcine pancreatic phospholipase A2 (PLA2). It has been assumed that this enzyme plays a role in carcinogenesis and that it could be a target in the tumour therapy. The results of this study show that both Pt(II) complexes inhibit the activity of the enzyme, though they bind to it in a different manner. While cisplatin interacts with the enzyme in an acompetitive manner, the stable interaction of [Pt(dach)Cl2] with PLA2 could not be detected under our experimental conditions. © 2013 Informa UK, Ltd.
Type: article
DOI: 10.3109/14756366.2012.666539
ISSN: 1475-6366
SCOPUS: 2-s2.0-84880057888
Appears in Collections:Faculty of Science, Kragujevac

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