1. University of Kragujevac Digital Archive
  2. University of Kragujevac
  3. Faculty of Science, Kragujevac
Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/9475
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dc.rights.licenseopenAccess-
dc.contributor.authorNesic, Maja-
dc.contributor.authorKamčeva T.-
dc.contributor.authorBugarčić, Živadin-
dc.contributor.authorPetkovic, Marijana-
dc.date.accessioned2020-09-19T18:22:38Z-
dc.date.available2020-09-19T18:22:38Z-
dc.date.issued2013-
dc.identifier.issn1475-6366-
dc.identifier.urihttps://scidar.kg.ac.rs/handle/123456789/9475-
dc.description.abstractThis work has been focused on testing the influence of two selected Pt(II) complexes cisplatin, Pt(NH3)2Cl2, and [Pt(dach)Cl2] on the activity of porcine pancreatic phospholipase A2 (PLA2). It has been assumed that this enzyme plays a role in carcinogenesis and that it could be a target in the tumour therapy. The results of this study show that both Pt(II) complexes inhibit the activity of the enzyme, though they bind to it in a different manner. While cisplatin interacts with the enzyme in an acompetitive manner, the stable interaction of [Pt(dach)Cl2] with PLA2 could not be detected under our experimental conditions. © 2013 Informa UK, Ltd.-
dc.rightsinfo:eu-repo/semantics/openAccess-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.sourceJournal of Enzyme Inhibition and Medicinal Chemistry-
dc.titleInhibitory effect of cisplatin and [Pt(dach)Cl2] on the activity of phospholipase A2-
dc.typearticle-
dc.identifier.doi10.3109/14756366.2012.666539-
dc.identifier.scopus2-s2.0-84880057888-
Appears in Collections:Faculty of Science, Kragujevac

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