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https://scidar.kg.ac.rs/handle/123456789/10068| Title: | Synthesis, antitumor activity and QSAR studies of some 4-aminomethylidene derivatives of edaravone |
| Authors: | Marković, Violeta     Eric Slavica Juranić Z. Stanojkovic, Tatjana Joksović, Ljubinka Ranković B. Kosanic, Marijana Joksović, Milan |
| Issue Date: | 2011 |
| Abstract: | A series of aminomethylidene derivatives obtained from 4-formyledaravone were synthesized and characterized by IR, NMR and elemental analysis. All the compounds were screened for their antitumor activity. The compound containing 5-phenylpyrazole moiety (3q) exhibited remarkable antitumor activity in in vitro assays, especially against human breast cancer MDA-MB-361 and MDA-MB-453 cell lines. The most important whole-molecule descriptors for antitumor activity on MDA-MB-453 cells belong to the group of quantum-chemical descriptors. © 2010 Elsevier Inc. All rights reserved. |
| URI: | https://scidar.kg.ac.rs/handle/123456789/10068 |
| Type: | article |
| DOI: | 10.1016/j.bioorg.2010.10.003 |
| ISSN: | 0045-2068 |
| SCOPUS: | 2-s2.0-78751647459 |
| Appears in Collections: | Faculty of Science, Kragujevac |
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| PaperMissing.pdf Restricted Access | 29.86 kB | Adobe PDF |  View/Open |
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