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Title: Synthesis, antitumor activity and QSAR studies of some 4-aminomethylidene derivatives of edaravone
Authors: Marković, Violeta
Eric Slavica
Juranić Z.
Stanojkovic, Tatjana
Joksović, Ljubinka
Ranković B.
Kosanic, Marijana
Joksović, Milan
Issue Date: 2011
Abstract: A series of aminomethylidene derivatives obtained from 4-formyledaravone were synthesized and characterized by IR, NMR and elemental analysis. All the compounds were screened for their antitumor activity. The compound containing 5-phenylpyrazole moiety (3q) exhibited remarkable antitumor activity in in vitro assays, especially against human breast cancer MDA-MB-361 and MDA-MB-453 cell lines. The most important whole-molecule descriptors for antitumor activity on MDA-MB-453 cells belong to the group of quantum-chemical descriptors. © 2010 Elsevier Inc. All rights reserved.
Type: article
DOI: 10.1016/j.bioorg.2010.10.003
ISSN: 0045-2068
SCOPUS: 2-s2.0-78751647459
Appears in Collections:Faculty of Science, Kragujevac

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