Synthesis, antitumor activity and QSAR studies of some 4-aminomethylidene derivatives of edaravone

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Назив:	Synthesis, antitumor activity and QSAR studies of some 4-aminomethylidene derivatives of edaravone
Аутори:	Marković, Violeta Eric Slavica Juranić Z. Stanojkovic, Tatjana Joksović, Ljubinka Ranković B. Kosanic, Marijana Joksović, Milan
Датум издавања:	2011
Сажетак:	A series of aminomethylidene derivatives obtained from 4-formyledaravone were synthesized and characterized by IR, NMR and elemental analysis. All the compounds were screened for their antitumor activity. The compound containing 5-phenylpyrazole moiety (3q) exhibited remarkable antitumor activity in in vitro assays, especially against human breast cancer MDA-MB-361 and MDA-MB-453 cell lines. The most important whole-molecule descriptors for antitumor activity on MDA-MB-453 cells belong to the group of quantum-chemical descriptors. © 2010 Elsevier Inc. All rights reserved.
URI:	https://scidar.kg.ac.rs/handle/123456789/10068
Тип:	article
DOI:	10.1016/j.bioorg.2010.10.003
ISSN:	0045-2068
SCOPUS:	2-s2.0-78751647459
Налази се у колекцијама:	Faculty of Science, Kragujevac