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https://scidar.kg.ac.rs/handle/123456789/10898
Назив: | Biomarkers for the prediction of early pulmonary embolism related mortality in spontaneous and provoked thrombotic disease |
Аутори: | Jovanovic Lj. Subota V. Stavric M. Subotic B. Dzudovic B. ![]() Novicic N. Matijasevic J. ![]() Miric M. Salinger S. ![]() Markovic Nikolic, Natasa ![]() Nikolić, Maja ![]() Miloradovic, Vladimir ![]() ![]() Kos L. Kovacevic Preradovic T. Marinkovic J. Kocev N. Obradović S. ![]() |
Датум издавања: | 2019 |
Сажетак: | © 2019 Elsevier B.V. Factors associated with provoked PE may influence a biomarker's predictive value for the primary outcome. The aim of this study was to investigate the value of BNP, cTnI, CRP and D-Dimer measurements taken soon after hospital admission for the prediction of 30-day PE-caused death in patients with spontaneous versus provoked PE.Data were extracted from a pool of 726 consecutive PE patients enrolled in the multicenter Serbian PE registry. Blood concentrations of BNP, cTnI, CRP and D-dimer were measured during the first 24 h of hospitalization. BNP blood level had strong predictive value for the primary outcome in spontaneous PE (c-statistics 0.943, 95% CI 0.882–1.000, p = .001) and a slightly lower predictive outcome in provoked PE (c-statistics 0.824, 95% CI 0.745–0.902, p < .001). NRI and IDI showed that none of the markers, when added to BNP, could improve Cox regression prediction models for 30-day PE-related mortality in either the spontaneous or provoked PE group. Blood levels of BNP measured during the first 24 h of hospital admission had an excellent predictive value for 30-day PE-related mortality in spontaneous PE and slightly lower predictive value in provoked PE, whereas CRP, cTnI and D-Dimer did not contribute significantly to the predictive value of BNP in either group. |
URI: | https://scidar.kg.ac.rs/handle/123456789/10898 |
Тип: | article |
DOI: | 10.1016/j.cca.2019.02.008 |
ISSN: | 0009-8981 |
SCOPUS: | 2-s2.0-85061634751 |
Налази се у колекцијама: | Faculty of Medical Sciences, Kragujevac |
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