Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/10898
Title: Biomarkers for the prediction of early pulmonary embolism related mortality in spontaneous and provoked thrombotic disease
Authors: Jovanovic Lj.
Subota V.
Stavric M.
Subotic B.
Dzudovic B.
Novicic N.
Matijasevic J.
Miric M.
Salinger S.
Markovic Nikolic, Natasa
Nikolić, Maja
Miloradovic, Vladimir
Kos L.
Kovacevic Preradovic T.
Marinkovic J.
Kocev N.
Obradović S.
Issue Date: 2019
Abstract: © 2019 Elsevier B.V. Factors associated with provoked PE may influence a biomarker's predictive value for the primary outcome. The aim of this study was to investigate the value of BNP, cTnI, CRP and D-Dimer measurements taken soon after hospital admission for the prediction of 30-day PE-caused death in patients with spontaneous versus provoked PE.Data were extracted from a pool of 726 consecutive PE patients enrolled in the multicenter Serbian PE registry. Blood concentrations of BNP, cTnI, CRP and D-dimer were measured during the first 24 h of hospitalization. BNP blood level had strong predictive value for the primary outcome in spontaneous PE (c-statistics 0.943, 95% CI 0.882–1.000, p = .001) and a slightly lower predictive outcome in provoked PE (c-statistics 0.824, 95% CI 0.745–0.902, p < .001). NRI and IDI showed that none of the markers, when added to BNP, could improve Cox regression prediction models for 30-day PE-related mortality in either the spontaneous or provoked PE group. Blood levels of BNP measured during the first 24 h of hospital admission had an excellent predictive value for 30-day PE-related mortality in spontaneous PE and slightly lower predictive value in provoked PE, whereas CRP, cTnI and D-Dimer did not contribute significantly to the predictive value of BNP in either group.
URI: https://scidar.kg.ac.rs/handle/123456789/10898
Type: article
DOI: 10.1016/j.cca.2019.02.008
ISSN: 0009-8981
SCOPUS: 2-s2.0-85061634751
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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