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dc.rights.licenserestrictedAccess-
dc.contributor.authorPavlović, Nenad-
dc.contributor.authorZdravkovic, Nemanja-
dc.contributor.authorDimitrov J.-
dc.contributor.authordjukic, aleksandar-
dc.contributor.authorArsenijevic, Nebojsa-
dc.contributor.authorVassilev T.-
dc.contributor.authorLukic, Miodrag-
dc.date.accessioned2021-04-20T14:47:01Z-
dc.date.available2021-04-20T14:47:01Z-
dc.date.issued2011-
dc.identifier.issn1521-6616-
dc.identifier.urihttps://scidar.kg.ac.rs/handle/123456789/10066-
dc.description.abstractIntravenous immunoglobulins (IVIG) are known to have a therapeutic effect in some autoimmune diseases. We examined the effect of IVIG and heme-exposed IVIG on the development of immune mediated diabetes induced in C57BL/6 mice by multiple low doses of streptozotocin. IVIG were used in a dose of 200mg/kg daily for 15days. Treatment with IVIG resulted in significant attenuation of diabetes induction as evaluated by glycemia, glycosuria and HbA1c level. Interestingly, heme-exposed IVIG had a still stronger antidiabetogenic effect. Serum levels of proinflammatory cytokines TNF-α, IFN-γ and IL17 were lower in IVIG treated animals when compared with controls, while IL10 level was higher. The number of CD4+Foxp3+ cells was higher in pancreatic lymph nodes of heme-exposed IVIG treated mice. Our results show that IVIG may downregulate diabetes induction possibly by favouring induction of T regulatory cells and suggest enhanced effect upon heme-binding to IVIG. © 2010 Elsevier Inc.-
dc.rightsinfo:eu-repo/semantics/restrictedAccess-
dc.sourceClinical Immunology-
dc.titleIntravenous immunoglobulins exposed to heme (heme IVIG) are more efficient than IVIG in attenuating autoimmune diabetes-
dc.typearticle-
dc.identifier.doi10.1016/j.clim.2010.10.010-
dc.identifier.scopus2-s2.0-79251598193-
Налази се у колекцијама:Faculty of Medical Sciences, Kragujevac

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