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Title: Reduction of some Pt(iv) complexes with biologically important sulfur-donor ligands
Authors: Jovanović, Snežana
Petrović, Biljana
Bugarčić, Živadin
van Eldik R.
Issue Date: 2013
Abstract: The reduction of the Pt(iv) complexes [PtCl4(bipy)], [PtCl 4(dach)] and [PtCl4(en)] by glutathione (GSH), l-cysteine (l-Cys) and l-methionine (l-Met) was investigated by stopped-flow spectrophotometry at pH 2.0 (in 0.01 M perchloric acid) and at pH 7.2 (in 25 mM Hepes buffer). Kinetic measurements were performed under pseudo-first order conditions with an excess of the reducing agent. The order of the reactivity of the studied complexes was [PtCl4(bipy)] > [PtCl4(dach)] > [PtCl4(en)], and reactivity of investigated reducing agents followed the order GSH > l-Cys > l-Met. All the reactions between the selected Pt(iv) complexes and the sulfur donor biomolecules proceeded by a reductive elimination process that included nucleophilic attack by the reducing agent on one of the mutually trans-coordinated chloride ligands, which led to a two-electron transfer process. The final products of the redox reactions were the corresponding reduced Pt(ii) complexes and the oxidized form of the reducing agents. © 2013 The Royal Society of Chemistry.
Type: article
DOI: 10.1039/c3dt50751c
ISSN: 1477-9226
SCOPUS: 2-s2.0-84878649305
Appears in Collections:Faculty of Science, Kragujevac

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