Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/10309
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dc.contributor.authorMarković, Violeta-
dc.contributor.authorJanicijevic A.-
dc.contributor.authorStanojkovic, Tatjana-
dc.contributor.authorKolundžija B.-
dc.contributor.authorSladić, Dušan-
dc.contributor.authorVujčić, Miroslava-
dc.contributor.authorJanovic, Barbara-
dc.contributor.authorJoksović, Ljubinka-
dc.contributor.authorDjurdjevic, Predrag-
dc.contributor.authorTodorovic N.-
dc.contributor.authorTrifunović, Snežana-
dc.contributor.authorJoksović, Milan-
dc.date.accessioned2021-04-20T15:25:23Z-
dc.date.available2021-04-20T15:25:23Z-
dc.date.issued2013-
dc.identifier.issn0223-5234-
dc.identifier.urihttps://scidar.kg.ac.rs/handle/123456789/10309-
dc.description.abstractA series of novel anthraquinone-thiosemicarbazone derivatives in a tautomerizable keto-imine form was synthesized and tested for their in vitro cytotoxic activity against human cancer cells (HeLa, MDA-MB-361, MDA-MB-453, K562, A549) and human normal MRC-5 cells. Several compounds efficiently inhibited cancer cell growth at micromolar concentrations, especially against K562 and HeLa cells. As determined by flow cytometric analysis, anthraquinone-thiosemicarbazone caused significant increase in the number of sub-G1 phase of HeLa cells and apoptosis in a concentration-dependent manner. Also, inhibition of caspase-3, -8, and -9 with specific caspase inhibitors reduced the apoptosis mediated by the tested compounds in HeLa cells. All anthraquinone-thiosemicarbazones exhibit calf thymus DNA-binding activity, but no cleavage of plasmid DNA was observed. © 2013 Elsevier Masson SAS. All rights reserved.-
dc.rightsrestrictedAccess-
dc.sourceEuropean Journal of Medicinal Chemistry-
dc.titleSynthesis, cytotoxic activity and DNA-interaction studies of novel anthraquinone-thiosemicarbazones with tautomerizable methylene group-
dc.typearticle-
dc.identifier.doi10.1016/j.ejmech.2013.03.071-
dc.identifier.scopus2-s2.0-84877040246-
Appears in Collections:Faculty of Science, Kragujevac

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