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Title: Polymorphisms of the GSTT1 and GSTM1 genes in women of central Serbia - Absence of association with uterine myoma
Authors: Arsenijevic, Slobodan
Ljujic, Biljana
Stosic, Ivana
Grujičić, Darko
Marinković D.
Milošević-Đorđević, Olivera
Issue Date: 2013
Abstract: Since glutathione S-transferase (GST) enzymes are involved in cellular protection, we aimed to determine the distribution of GSTT1 and GSTM1 null genotypes in women in central Serbia in order to assess the risk of development of uterine myoma. The study consisted of 34 clinically diagnosed uterine myoma patients and 35 healthy control women. Analyses of GST polymorphism were carried out by multiplex PCR. Our results showed no significant differences in the GSTT1 and GSTM1 null genotypes between the patients and controls. Using the GSTT1 positive/GSTM1 positive combination as reference, there was no statistically significant risk of uterine myoma with the combination of GSTT1 null and GSTM1 null genotypes. We conclude that polymorphism of both GSTT1 and GSTM1 genes, alone or in combination, did not present the main risk for uterine myoma in women from central Serbia.
Type: article
DOI: 10.2298/ABS1302415A
ISSN: 0354-4664
SCOPUS: 2-s2.0-84876956953
Appears in Collections:Faculty of Medical Sciences, Kragujevac
Faculty of Science, Kragujevac

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