Please use this identifier to cite or link to this item: https://scidar.kg.ac.rs/handle/123456789/10524
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dc.contributor.authorVolarevic, Vladislav-
dc.contributor.authorMilovanovic, Marija-
dc.contributor.authorĐeković Kesić A.-
dc.contributor.authorBugarčić, Živadin-
dc.contributor.authorArsenijevic, Nebojsa-
dc.date.accessioned2021-04-20T15:58:42Z-
dc.date.available2021-04-20T15:58:42Z-
dc.date.issued2012-09-01-
dc.identifier.issn18208665-
dc.identifier.urihttps://scidar.kg.ac.rs/handle/123456789/10524-
dc.description.abstractIn recent years, gold(III) complexes have attracted great interest because of their cytotoxicity to cancer cells. We investigated the cytotoxic effects of three newly synthesised gold(III) complexes, [Au(en)Cl 2] + (dichloride (ethylendiamine) aurate(III)-ion), [Au(dach)Cl 2] (dichloride (1,2- diaminocyclohexane) aurate(III)-ion) and [Au(bipy)Cl 2] + (dichloride (2,2'-bipyridyl) aurate(III)-ion), on the murine BCL-1 B lineage leukaemia cell line. The cytotoxicity of these gold(III) complexes was evaluated by cytotoxic assay (MTT test). The results showed that all of the tested gold(III) complexes displayed a cytotoxic effect on BCL-1 cells. The concentration decrease was followed by a marked increase in BCL-1 cell viability. At a concentration of 125 μM, which we suppose could be used in vivo, the [Au(bipy)Cl 2] + complex showed the greatest cytotoxic effects among the tested gold(III) complexes and similar cytotoxicity asto the cisplatinum that we used as control. Among the tested gold(III) complexes, [Au(en)Cl 2] +was the least cytotoxic to BCL-1 cells. In line with the obtained results, we suggest that the [Au(bipy)Cl 2] + complex should be tested in vivo in experimental models of B cell leukaemia.-
dc.relation.ispartofSerbian Journal of Experimental and Clinical Research-
dc.titleCytotoxic effects of selected gold(III) complexes on the murine BCL-1 B lineage leukaemia cell line-
dc.typejournal article-
dc.identifier.doi10.5937/sjecr13-1721-
dc.identifier.scopus84867834490-
Appears in Collections:Faculty of Medical Sciences, Kragujevac

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